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. 2021 Jun 7;13(11):2837. doi: 10.3390/cancers13112837

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Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Folate transport pathway. The color scheme for the folate pathway genes reflects the number of studies that found a significant pharmacogenetic association with MTX exposure. AICAR: 5-aminoimidazole-4-carboxamide ribonucleotide; DHF: dihydrofolate; dUMP: deoxyuridine monophosphate; dTMP: deoxythymidine monophosphate; fAICAR: 5-formamidoimidazole-4-carboxamide ribonucleotide; FOL: folate; Glu: glutamated; FOLH1: N-acetyl-L-aspartyl-L-glutamate peptidase; I HCOOH: formic acid; MTX: methotrexate; Poly: prefix, meaning more than one, SAM: S-adenosyl methionine, SAH: S-adenosyl-l-homocysteine; SHMT1: serine hydroxymethyltransferase 1; THF: tetrahydrofolate.