Table 1.

Transporter Genes That Significantly Affect Methotrexate Exposure.

Gene Name	Variants	Effect of Variant on Methotrexate Exposure	References
ABCB1	rs9282564	↑	[20,21]
ABCG2	rs12505410	↓	[22]
ABCG2	rs13120400	↑	[22]
ABCG2	rs13137622	↓	[22]
ABCG2	rs2231142	↑	[20,23,24,25,26,27]
ABCC2	rs3740065	↑ *|↓	[22,28,29*,30*,31*]
ABCC2	rs3740066	↑ *|↓	[20,27*,29*]
ABCC2	rs717620	↑ *|↓	[20,22,23,27,28,29,30*,31*,32,33,34,35,36]
ABCC3	rs4793665	↓	[20,36]
ABCC3	rs9895420	↓	[36]
ABCC4	rs10219913	↑	[28,29]
ABCC4	rs7317112	↑	[28,29]
ABCC4	rs868853	↓	[29,31,37]
ABCC4	rs9516519	↑ *|↓	[28*,29,31*]
SLC19A1	rs1051266	↑ *|↓	[20,21,22,26*,27,28,29*,33,34,35,38,39,40*,41*,42*,43*]
SLC19A1	rs1051296	↑	[44]
SLC19A1	rs61510559	↓	[23,25,45,46,47]
SLCO1A2	rs4149009	↓	[27,29,48]
SLCO1B1	rs10841753	↑ *|↓	[38,49*,50]
SLCO1B1	rs11045787	↑	[49]
SLCO1B1	rs11045818	↑ *|↓	[21,49*,50*]
SLCO1B1	rs11045813	↑	[50]
SLCO1B1	rs11045819	↓	[21,51]
SLCO1B1	rs11045821	↓	[50]
SLCO1B1	rs11045825	↓	[50]
SLCO1B1	rs11045870	↓	[50]
SLCO1B1	rs11045872	↓	[22,49,50]
SLCO1B1	rs11045879	↑ *|↓	[22,25*,29,33,35*,49,50*,52]
SLCO1B1	rs11045892	↓	[50]
SLCO1B1	rs11045897	↑	[38,53]
SLCO1B1	rs16923647	↓	[50]
SLCO1B1	rs17328763	↑	[49]
SLCO1B1	rs2169969	↓	[50]
SLCO1B1	rs2306283	↑ *|↓	[27*,33,38,54]
SLCO1B1	rs2900476	↓	[22,49]
SLCO1B1	rs34671512	↓	[51]
SLCO1B1	rs4149056	↑	[21,22,27,28,32,33,34,35,38,43,49,50,51,52,54,55]
SLCO1B1	rs4149076	↓	[49]
SLCO1B1	rs4149081	↑ *|↓	[22*,49,50*,25*,53*]
SLCO1B1	rs59502379	↑	[51]

Genes and variants not found in the table above do not significantly affect methotrexate exposure. Please see Table S2 in Supplementary for full list of genes and variants. Underlined references found a significant association between variant and methotrexate exposure. * Indicates the studies that showed increased MTX exposure when there were conflicting reports for a variant. ↑ Indicates that the variant is associated with increased/higher methotrexate exposure. ↓ Indicates that the variant is associated with decreased/lower methotrexate exposure.