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. 2021 Jun 7;22(11):6135. doi: 10.3390/ijms22116135

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Impact of capsaicin (CAP) on substructures of the pilosebaceous unit. Keratinocytes and their stem cell precursors express TRPV1 (green tetramer, not to scale) and, when stimulated with CAP, show increased expression of growth inhibition factors and decreased growth promotion factors, accompanied by increased apoptosis. CAP activation inhibits lipid synthesis in the sebaceous gland (SG). Additionally, low dose CAP stimulation in the SG has increased proliferation, but high dose CAP stimulation leads to cell death.