Table 2.

The effects of individual drugs on the activity of basolateral membrane transporters causing the influx of tenofovir and other medications from this group into the cell, and of the apical membrane transporters causing their efflux from the cell. The effect of drugs on blood tenofovir levels.

Tenofovir’s Transporters Type and Effect of Drugs on Transporter Activity		Drugs Effect on 1 Blood Tenofovir Levels
hOAT1 [16]	Probenecid-inhibition	Aciclovir-increase
MRP-4 [16,41]	probenecid-inhibition dipyridamole-inhibition NSAIDs-inhibition cidofovir-inhibition aciclovir-inhibition valaciclovir-inhibition ganciclovir-inhibition valganciclovir-inhibition
MRP-2 [16]	Ritonavir is a competitor for the MRP-2, thus leading to increased tenofovir concentration in the cell	Ritonavir-increase