Table 1.

Composition of various ethosomal formulations based on the experimental design and the resultant values of observed response.

Formula	Independent Variables		Dependent Response			PDI
	X1 (%)	X2 (%)	Y1 (nm)	Y2 (%)	Y3 (µg/cm2·h)
F1	0.39	7.5	152 ± 2.5	61.4 ± 1.4	0.49 ± 0.025	0.250
F2	0.5	10	142 ± 1.7	74 ± 2.6	0.55 ± 0.035	0.230
F3	0.75	7.5	154 ± 2.0	66 ± 1.7	0.46 ± 0.04	0.311
F4	0.75	7.5	166 ± 1.5	70.2 ± 1.9	0.45 ± 0.035	0.290
F5	1	10	150 ± 1.4	76.3 ± 1.3	0.51 ± 0.04	0.271
F6	0.5	5	180 ± 2.1	55.8 ± 2.2	0.41 ± 0.05	0.321
F7	1	5	192 ± 2.0	58.9 ± 2.4	0.37 ± 0.031	0.401
F8	0.75	7.5	160 ± 1.6	68.6 ± 1.7	0.44 ± 0.038	0.304
F9	0.75	7.5	168 ± 1.8	71.5 ± 2.5	0.47 ± 0.035	0.281
F10	0.75	11.0	118 ± 1.5	77 ± 1.2	0.59 ± 0.04	0.214
F11	1.10	7.5	180 ± 2.5	73.5 ± 1.6	0.42 ± 0.038	0.282
F12	0.75	3.96	218 ± 3.0	50.2 ± 1.8	0.33 ± 0.015	0.336

X₁: phospholipid concentration; X₂: ethanol concentration; Y₁ vesicular size; Y₂: encapsulation efficiency; Y₃: flux.