Table 2.

Statistical and regression analysis results for all responses.

Source	Y1		Y2		Y3
	F-Value	p-Value	F-Value	p-Value	F-Value	p-Value
Model	42.04	<0.0001 *	42.74	<0.0001 *	160.61	<0.0001 *
X1	5.68	0.0410 *	9.59	0.0241 *	22.79	0.0010 *
X2	78.39	<0.0001 *	0.2856	<0.0001 *	298.4	<0.0001 *
Lack of Fit	2.43	0.2489	1.81	0.3349	1.08	0.5160
R2 analysis
R2	0.9033		0.9047		0.9727
Adjusted R2	0.8818		0.8836		0.9667
Predicted R2	0.8052		0.8310		0.9483
Adequate Precision	17.707		17.681		34.550
Model	Linear		Linear		Linear
Remark	Suggested		Suggested		Suggested

X₁: phospholipid concentration; X₂: ethanol concentration; Y₁: vesicular size; Y₂: encapsulation efficiency; Y₃: flux; *: significant.