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. 2021 Jun 7;18(11):6144. doi: 10.3390/ijerph18116144

Table 1.

Population characteristics (Mean (range)).

Variables Total Subjects (n = 162) Subjects with Illumina DNA Methylation Levels (n = 34) p-Value
Maternal age (year) 32.2 (20–43) 32.6 (22.7–38.1) 0.90
Pre-pregnancy BMI (Kg/m2) 21.1 (15.4–34.1) 20.9 (17.3–28.2) 0.57
Maternal weight gain (Kg) 12.4 (8.6–16.2) 12.6 (8.0–19.0) 0.93
Birth weight (g) 3121 (2400–3880) 2928 (2520–3880) 0.15
BPA levels (μg/g creatinine)
1st trimester 2.46 (0.01–46.5) 2.64 (0.01–24.1) 0.74
2nd trimester 4.53 (0.01–85.6) 6.14 (0.01–32.4) 0.30
3rd trimester 11.31 (0.02–153.0) 17.23 (0.03–114.9) 0.61
BPA stratified by the 75th percentile * Low exposure group
1st trimester (<1.4 μg/g creatinine) 0.10 (0.01–1.3) 0.71 (0.01–8.4) 0.37
2nd trimester (<3.3 μg/g creatinine) 0.51 (0.01–3.3) 0.48
3rd trimester (<5.0 μg/g creatinine 0.31 (0.01–4.3) 0.86
High exposure group
1st trimester (>1.4 μg/g creatinine) 9.72 (1.4–46.5) 34.53 (12.8–114.9) NA
2nd trimester (>3.3 μg/g creatinine) 18.07 (3.7–85.6) NA
3rd trimester (>5.0 μg/g creatinine) 41.6 (5.0–153.0) 0.38

Sample sizes in subjects with Illumina DNA methylation were 10, 10, and 14 in the first, second, and third trimesters, respectively. * In the subgroup (n = 34), prenatal BPA exposure groups were categorized into low (< 9.5 μg/g creatinine) and high (> 9.5 μg/g creatinine) exposure group based on the 75th percentile. Among them, 8 subjects were in the high BPA exposure group; 1, 2, and 5 were in the first, second, and three trimesters. In total subjects, prenatal BPA exposure groups were categorized into low and high exposure group based on the 75th percentile in the 1st trimester (1.4 μg/g creatinine), 2nd trimester (3.3 μg/g creatinine), and 3rd trimester (5.0 μg/g creatinine). NA: not available.