Table 4.
Adjusted odds ratios (95% CI) between cord DNA methylation levels (cutoff 50th percentile) at 8 CpG sites and low birth weight (<2500 g) calculated in an adjusted logistic regression model.
| Genes | DNA Methylation Levels at CpG Sites (Cutoff by Median) | Odds Ratio | 95% CI | p-Value |
|---|---|---|---|---|
| DST | cg01502353 (methylation >88% vs. <88%) | 1.06 | 0.99–1.14 | 0.09 |
| CSF1R | cg05524038 CpG2nd (methylation >93% vs. <93%) | 1.03 | 0.95–1.11 | 0.50 |
| cg05524038 1st and 2nd CpG sites (methylation >91% vs. <91%) | 0.97 | 0.89–1.04 | 0.37 | |
| TG | cg07349217 (methylation >96% vs. <96%) | 1.01 | 0.94–1.09 | 0.74 |
| DST | cg19768311 (methylation >91% vs. <91%) | 0.96 | 0.89–1.03 | 0.23 |
| KCNB2 | cg23244463 CpG3rd (methylation >98% vs. <98%) | 1.00 | 0.94–1.09 | 0.82 |
| cg23244463 1 to 4 CpGs (methylation >96.8% vs. <96.8%) | 1.00 | 0.94–1.08 | 0.86 | |
| HNF4A | cg27420224 CpG1st (methylation>86% vs. <86%) | 0.97 | 0.90–1.04 | 0.40 |
| cg27420224 1 to 4 CpGs (methylation >79% vs. <79%) | 1.01 | 0.94–1.09 | 0.74 | |
| DHRS9 | cg27640254 CpG2nd (methylation >82.5% vs. <82.5%) | 1.10 | 1.00–1.21 | 0.047 |
| cg27640254 1st and 2nd CpGs (methylation >88.5% vs. <88.5%) | 0.96 | 0.88–1.03 | 0.26 |
cg19427642 site: not available due to small sample sizes in DNA methylation level. Model adjusted for maternal age, gestational age, pre-pregnancy BMI, birth sex, and parity.