Table 4.
Combined analysis of microRNA gene polymorphisms in RPL patients and controls.
| Combination Genotype | Controls n = 227 n (%) |
RPL n = 388 n (%) |
AOR (95% CI) a | p b | FDR-p c |
|---|---|---|---|---|---|
| miR-604A>G, miR-608C>G | |||||
| AA/CC | 15 (6.6) | 39 (10.1) | 1.000 (reference) | ||
| AA/CG + GG | 58 (25.6) | 132 (34.0) | 0.870 (0.445–1.702) | 0.684 | 0.846 |
| AG + GG/CC | 33 (14.5) | 54 (13.9) | 0.624 (0.298–1.305) | 0.210 | 0.315 |
| AG + GG/CG + GG | 121 (53.3) | 163 (42.0) | 0.521 (0.275–0.990) | 0.047 | 0.141 |
| miR-604A>G, miR-631I>D | |||||
| AA/II | 65 (28.6) | 155 (39.9) | 1.000 (reference) | ||
| AA/ID + DD | 8 (3.5) | 16 (4.1) | 0.841 (0.343–2.064) | 0.705 | 0.846 |
| AG + GG/II | 139 (61.2) | 202 (52.1) | 0.611 (0.425–0.879) | 0.008 | 0.024 |
| AG + GG/ID + DD | 15 (6.6) | 15 (3.9) | 0.432 (0.197–0.950) | 0.037 | 0.056 |
| miR-604A>G, miR-938G>A | |||||
| AA/GG | 71 (31.3) | 167 (43) | 1.000 (reference) | ||
| AA/GA + GA | 2 (0.9) | 4 (1.0) | 0.852 (0.153–4.763) | 0.856 | 0.856 |
| AG + GG/GG | 144 (63.4) | 213 (54.9) | 0.637 (0.448–0.905) | 0.012 | 0.018 |
| AG + GG/GA + GA | 10 (4.4) | 4 (1.0) | 0.171 (0.052–0.565) | 0.004 | 0.012 |
| miR-604A>G, miR-1302-3C>T | |||||
| AA/CC | 61 (26.8) | 154 (39.6) | 1.000 (reference) | ||
| AA/CT + TT | 11 (4.9) | 17 (4.4) | 0.617 (0.273–1.394) | 0.506 | 0.846 |
| AG + GG/CC | 130 (57.3) | 195 (50.3) | 0.599 (0.412–0.864) | 0.022 | 0.044 |
| AG + GG/CT + TT | 25 (11.0) | 22 (5.7) | 0.351 (0.182–0.673) | 0.006 | 0.018 |
| miR-608C>G, miR-938G>A | |||||
| CC/GG | 48 (21.1) | 91 (23.5) | 1.000 (reference) | ||
| CG + GG/GG | 167 (73.6) | 289 (74.5) | 0.914 (0.613–1.361) | 0.657 | 0.657 |
| CG + GG/GA + AA | 12 (5.3) | 6 (1.5) | 0.268 (0.095–0.762) | 0.014 | 0.021 |
| miR-631I>D, miR-938G>A | |||||
| II/GG | 192 (84.6) | 349 (89.9) | 1.000 (reference) | ||
| II/GA + AA | 12 (5.3) | 8 (2.1) | 0.367 (0.147–0.914) | 0.031 | 0.186 |
| ID + DD/GG | 23 (10.1) | 31 (8) | 0.752 (0.426–1.329) | 0.327 | 0.382 |
| miR-938G>A, miR-1302-3C>T | |||||
| GG/CC | 182 (80.2) | 342 (88.1) | 1.000 (reference) | ||
| GG/CT + TT | 33 (14.5) | 38 (9.8) | 0.617 (0.374–1.017) | 0.135 | 0.444 |
| GA + AA/CC | 9 (4.0) | 7 (1.8) | 0.371 (0.141–0.974) | 0.210 | 0.077 |
| GA + AA/CT + TT | 3 (1.3) | 1 (0.3) | 0.351 (0.058–0.127) | 0.481 | 0.694 |
Abbreviations: RPL, recurrent pregnancy loss; AOR, adjusted odds ratio; CI, confidence interval; FDR-p, false discovery rate-adjusted p; a Adjusted for age. b Fisher’s exact test. c False-positive discovery rate (FDR)-adjusted p-value. Bold numbers indicate significant p-values.