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. 2021 Jun 7;13(11):2841. doi: 10.3390/cancers13112841

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Antimetastatic effect of tTF-fusion proteins tTF-NGR (NGR) and tTF-RGD (RGD). Antimetastatic effect of two tTF-fusion proteins systemically given at 3 mg/kg body weight every 2–3 days x5 in a syngeneic B-16 melanoma model growing in C57BL6 mice. Freedom from treatment failure: spontaneous metastasis after surgical removal of the subcutaneous primary tumors was clinically observed (e.g., inactivity, dyspnea, weight loss, fur changes), subsequently the mice were sacrificed (survival time) and the lungs of the animals were examined for lung metastasis. When compared with saline controls tTF-NGR revealed significant superiority (Mann-Whitney test, p = 0.009). PBS, saline control. Unpublished data.