Table 1.
Cumulative incidence function/event rates of primary outcomes and 95% confidence intervals depending on sex and treatment group.
| All Patients n = 53,971 (100%) |
Female Sex n = 45,707 (84.7%) |
Male Sex n = 8264 (15.4%) |
p Value | |
|---|---|---|---|---|
| Death from any case LPF: | <0.001 | |||
| 1-year rate | 8.4% (8.1–8.6%) | 7.6% (7.3–7.8%) | 12.6% (11.8–13.4%) | |
| 2-year rate | 14.8% (14.5–15.2%) | 13.5% (13.1–13.9%) | 21.7% (20.6–22.7%) | |
| 5-year rate | 34.5% (34.0–35.1%) | 32.4% (31.8–33.0%) | 45.9% (44.4–47.4%) | |
| 8-year rate | 52.2% (51.4–53.0%) | 49.8% (48.9–50.7%) | 65.0% (63.0–66.9%) | |
| Death from any case RTSA: | <0.001 | |||
| 1-year rate | 9.1% (8.7–9.7%) | 8.4% (7.9–8.9%) | 14.2% (12.5–15.9%) | |
| 2-year rate | 16.2% (15.6–16.9%) | 15.2% (14.5–15.9%) | 23.1% (21.0–25.3%) | |
| 5-year rate | 39.4% (38.2–40.7%) | 37.7% (36.3–39.0%) | 51.6% (48.0–55.1%) | |
| 8-year rate | 59.9% (57.7–62.1%) | 58.3% (55.8–60.6%) | 71.0% (65.0–76.1%) | |
| Major adverse event LPF: | <0.001 | |||
| 1-year rate | 12.4% (12.1–12.8%) | 11.3% (11.0–11.7%) | 18.1% (17.2–19.1%) | |
| 2-year rate | 21.3% (20.9–21.8%) | 19.7% (19.2–20.1%) | 30.1% (28.9–31.3%) | |
| 5-year rate | 44.7% (44.1–45.3%) | 42.4% (41.7–43.0%) | 57.1% (55.6–58.5%) | |
| 8-year rate | 62.9% (62.1–63.6%) | 60.6% (59.7–61.4%) | 74.8% (73.0–76.5%) | |
| Major adverse event RTSA: | <0.001 | |||
| 1-year rate | 14.2% (13.6–14.8%) | 13.2% (12.6–13.9%) | 20.2% (18.3–22.2%) | |
| 2-year rate | 24.1% (23.3–24.9%) | 22.9% (22.0–23.7%) | 32.4% (30.0–34.8%) | |
| 5-year rate | 50.0% (48.7–51.2%) | 48.0% (46.7–49.4%) | 62.9% (59.4–66.2%) | |
| 8-year rate | 68.4% (66.4–70.4%) | 66.7% (64.5–68.7%) | 79.8% (73.9–84.4%) | |
| Thromboembolic event LPF: | <0.001 | |||
| 1-year rate | 11.0% (10.7–11.3%) | 10.2% (9.9–10.6%) | 15.1% (14.2–16.0%) | |
| 2-year rate | 18.9% (18.5–19.3%) | 17.6% (17.2–18.1%) | 25.5% (24.4–26.6%) | |
| 5-year rate | 40.9% (40.3–41.5%) | 38.8% (38.2–39.4%) | 51.8% (50.3–53.3%) | |
| 8-year rate | 58.5% (57.8–59.3%) | 56.5% (55.6–57.3%) | 69.5% (67.6–71.3%) | |
| Thromboembolic event RTSA: | <0.001 | |||
| 1-year rate | 12.2% (11.6–12.8%) | 11.5% (10.9–12.1%) | 16.8% (15.1–18.6%) | |
| 2-year rate | 20.9% (20.2–21.7%) | 19.9% (19.1–20.7%) | 27.8% (25.5–30.1%) | |
| 5-year rate | 45.9% (44.7–47.2%) | 44.4% (43.0–45.7%) | 56.7% (53.1–60.1%) | |
| 8-year rate | 64.6% (62.5–66.6%) | 63.4% (61.1–65.6%) | 72.6% (66.8–77.5%) | |
| Surgical complications only after discharge LPF: | 0.34 | |||
| 1-year rate | 9.5% (9.3–9.8%) | 9.4% (9.1–9.7%) | 10.4% (9.6–11.1%) | |
| 2-year rate | 11.1% (10.8–11.4%) | 11.0% (10.7–11.3%) | 11.8% (11.0–12.6%) | |
| 5-year rate | 12.0% (11.7–12.3%) | 11.9% (11.5–12.2%) | 12.5% (11.7–13.3%) | |
| 8-year rate | 12.2% (11.9–12.7% | 12.1% (11.8–12.5%) | 12.7% (11.8–13.5%) | |
| Surgical complications only after discharge RTSA: | <0.001 | |||
| 1-year rate | 4.0% (3.6–4.3%) | 3.3% (3.0–3.7%) | 8.2% (6.9–9.5%) | |
| 2-year rate | 4.7% (4.3–5.1%) | 4.0% (3.7–4.4%) | 8.9% (7.6–10.3%) | |
| 5-year rate | 6.2% (5.7–6.7%) | 5.5% (5.1–6.1%) | 10.7% (9.1–12.4%) | |
| 8-year rate | 7.2% (6.6–7.9%) | 6.7% (6.0–7.4%) | 10.7% (9.1–12.4%) | |
| Surgical complications incl. index case LPF: | <0.001 | |||
| 1-year rate | 16.1% (15.8–16.5%) | 15.6% (15.2–15.91%) | 19.1% (18.2–20.1%) | |
| 2-year rate | 17.6% (17.2–17.9%) | 17.0% (16.6–17.4%) | 20.3% (19.3–21.3%) | |
| 5-year rate | 18.3% (17.9–18.7%) | 17.8% (17.4–18.2%) | 20.9% (19.9–21.9%) | |
| 8-year rate | 18.5% (18.1–18.9%) | 18.0% (17.6–18.5%) | 21.0% (20.0–22.1%) | |
| Surgical complications incl. index case RTSA: | <0.001 | |||
| 1-year rate | 12.1% (11.5–12.7%) | 10.9% (10.4–11.5%) | 19.8% (18.0–21.7%) | |
| 2-year rate | 12.7% (12.1–13.3%) | 11.6% (11.0–12.2%) | 20.4% (18.6–22.4%) | |
| 5-year rate | 14.0% (13.4–14.7%) | 12.8% (12.2–13.5%) | 22.0% (20.0–24.2%) | |
| 8-year rate | 14.9% (14.2–15.7%) | 13.9% (13.1–14.7%) | 22.0% (20.0–24.2%) | |
| Any secondary surgery LPF: | 0.32 | |||
| 1-year rate | 9.0% (8.7–9.3%) | 8.9% (8.6–9.2%) | 9.8% (9.1–10.5%) | |
| 2-year rate | 10.5% (10.2–10.8%) | 10.3% (10.0–10.7%) | 11.0% (10.3–11.8%) | |
| 5-year rate | 11.2% (10.9–11.5%) | 11.1% (10.7–11.4%) | 11.7% (10.9–12.6%) | |
| 8-year rate | 11.3% (11.0–11.7%) | 11.2% (10.9–11.6%) | 11.9% (11.1–12.7%) | |
| Any secondary surgery RTSA: | <0.001 | |||
| 1-year rate | 3.6% (3.2–3.9%) | 3.0% (2.7–3.3%) | 7.3% (6.1–8.5%) | |
| 2-year rate | 4.3% (3.9–4.6%) | 3.7% (3.4–4.1%) | 7.9% (6.7–9.3%) | |
| 5-year rate | 5.8% (5.3–6.3%) | 5.2% (4.8–5.7%) | 9.4% (7.9–11.1%) | |
| 8-year rate | 6.8% (6.2–7.5%) | 6.4% (5.7–7.2%) | 9.4% (7.9–11.1%) | |
| Change to RTSA (only LPF): | 0.31 | |||
| 1-year rate | 2.7% (2.6–2.9%) | 2.8% (2.6–3.0%) | 2.6% (2.2–3.0%) | |
| 2-year rate | 3.4% (3.2–3.6%) | 3.5% (3.3–3.7%) | 3.0% (2.6–3.4%) | |
| 5-year rate | 3.7% (3.5–3.9%) | 3.8% (3.6–4.0%) | 3.2% (2.8–3.7%) | |
| 8-year rate | 3.8% (3.6–4.0%) | 3.9% (3.7–4.2%) | 3.3% (2.8–3.7%) | |
| Minor outpatient complications LPF: | <0.001 | |||
| 1-year rate | 20.8% (20.4–21.2%) | 20.9% (20.4–21.3%) | 20.3% (19.3–21.3%) | |
| 2-year rate | 24.9% (24.5–25.3%) | 25.2% (24.7–25.6%) | 23.5% (22.5–24.6%) | |
| 5-year rate | 30.6% (30.1–31.1%) | 31.1% (30.6–31.7%) | 27.8% (26.7–29.0%) | |
| 8-year rate | 33.4% (32.9–34.0%) | 34.1% (33.5–34.7%) | 29.8% (28.5–31.1%) | |
| Minor outpatient complications RTSA: | 1 | |||
| 1-year rate | 21.9% (21.2–22.6%) | 21.5% (20.8–22.3%) | 24.0% (22.1–26.1%) | |
| 2-year rate | 25.8% (25.0–26.6%) | 25.7% (24.9–26.5%) | 26.6% (24.5–28.7%) | |
| 5-year rate | 31.7% (30.8–32.6%) | 31.9% (30.9–32.9%) | 30.4% (28.0–32.9%) | |
| 8-year rate | 34.0% (32.9–35.2%) | 34.6% (33.3–35.9%) | 30.8% (28.3–33.3%) | |