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. 2021 May 31;12:632581. doi: 10.3389/fimmu.2021.632581

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Copyright © 2021 Schreiber, Hammers, Kaasch, Schraven, Dudeck and Kahlfuss

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Metabolic Interdependency of Th2 cell-mediated type 2 immunity and the Tumor Microenvironment (TME): The TME is characterized by a high energy demand, glycolysis, and lipid metabolism. This reduces 0₂ and glucose availability within the TME, while free FA, other lipids and lactate is found to be elevated. These conditions affect Th2 cells and their effector functions (e.g. cytokine production of IL-4, IL-5, and IL-13) and, secondary, eosinophil mobilization and activation. 0₂, Oxygen; IL, Interleukin; Ox., Oxidation; FA, Fatty acid(s).