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Molecular glue library (MGL) design and properties. (A) Design strategy around the IMiD core scaffold. (B) Docking poses of selected library scaffolds in the binding pocket of Cereblon (PDB: 4TZ4) illustrating 3D spatial coverage. The IMiD core scaffold is highlighted in green. (C) Physicochemical properties of the library compounds: A log P vs molecular weight colored by polar surface area.
