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. 2021 May 27;64(11):7296–7311. doi: 10.1021/acs.jmedchem.0c01313

Table 1. In Vitro Activity Profiles of Lead Compounds 6 and 7.

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    EC50 (nM)a
  
cmpd R MV4-11 MHH-CALL-4 MB002 MB004 HD-MB03 CRBN IC50 (nM)a
6 (SJ6986) 2-OCF3 1.5 0.4 726 336 3583 15
7 (SJ7023) 2-Me, 3-Cl 52 4.4 5009 1104 >8 16
a

All values are the mean of ≥2 independent experiments.