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. 2021 Jun 8;24(2):571. doi: 10.3892/mmr.2021.12210

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Copyright: © Zhang et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 4. — Baicalin can alleviate pathological lung damage in Mycoplasma pneumoniae pneumonia model mice by regulating miR-221. (A) To further investigate the relationship between Baicalin and miR-221, mice were transfected with miR-221 mimics, and the expression of miR-221 in lung tissue after transfection was confirmed to be upregulated by RT-qPCR. (B) RT-qPCR was used to detect the expression levels of miR-221 in different groups. (C) H&E staining (scale bar, 50 µm). (D) Inflammatory infiltration score. *P<0.05 vs. Control group; ^#P<0.05 vs. Model group; ^$P<0.05 vs. Baicalin group; ^&P<0.05 vs. miR-221 mimics group. miR-221, microRNA-221; ns, not significant; RT-qPCR, reverse transcription-quantitative PCR.