Table 3 -. Individual MACE risk (HR) of all studied variables.
| Overall characteristics | HR (95% CI) | P-value** |
|---|---|---|
| Demographic | ||
| Age, years | 1.012 (1.002 - 1.023) | 0.023 |
| Male sex, n (%) | 0.859 (0.703 - 1.050) | 0.139 |
| BMI, kg/m2 | 1.009 (0.990 - 1.028) | 0.365 |
| Traditional risk factors | ||
| Smoking status, n (%) | 0.931 (0.788 - 1.101) | 0.405 |
| Diabetes, n (%) | 1.300 (1.099 - 1.537) | 0.002 |
| Dyslipidemia, n (%) | 1.134 (0.841 - 1.529) | 0.410 |
| CAD family history, n (%) | 0.889 (0.735 - 1.076) | 0.226 |
| Physical inactivity, n (%) | 1.453 (1.210 - 1.744) | <0.0001 |
| Hypertension, n (%) | 1.313 (1.083 - 1.592) | 0.006 |
| Alcohol>300gr/week, n (%) | 1.374 (1.123 - 1.681) | 0.002 |
| SBP, mmHg | 0.998 (0.994 - 1.002) | 0.348 |
| DBP, mmHg | 0.995 (0.988 - 1.002) | 0.176 |
| Laboratory Risk Factors | ||
| Fasting glucose, mg/dL | 1.002 (1.001 - 1.004) | 0.002 |
| Total cholesterol, mg/dL | 1.000 (0.998 - 1.002) | 0.911 |
| LDL, mg/dL | 0.999 (0.997 - 1.001) | 0.323 |
| HDL, mg/dL | 0.989 (0.982 - 0.997) | 0.007 |
| Triglycerides, mg/dL | 1.001 (1.000 - 1.001) | 0.042 |
| Apolipoprotein B, mg/dL | 1.001 (0.998 - 1.003) | 0.652 |
| Lipoprotein (a)>30mg/dL, n (%) | 1.163 (0.985 - 1.374) | 0.074 |
| Homocysteine>10mg/dL, n (%) | 1.001 (0.819 - 1.225) | 0.989 |
| CRP>3 mg/L, n (%) | 1.408 (1.193 - 1.661) | <0.0001 |
| Fibrinogen, mg/dL | 1.002 (1.001 - 1.003) | <0.0001 |
| Leucocytes, mg/dL | 1.049 (1.010 - 1.089) | 0.014 |
| Hemoglobin, mg/dL | 0.926 (0.870 - 0.987) | 0.017 |
| Clinical risk factors | ||
| Heart rate, beat/min. | 1.011 (1.004 - 1.017) | 0.001 |
| Cr Clearance*<60ml/min, n (%) | 1.349 (1.040 - 1.749) | 0.024 |
| Ejection fraction<55, n (%) | 1.650 (1.393 - 1.955) | <0.0001 |
| Multivessel disease, n (%) | 1.908 (1.608 - 2.265) | <0.0001 |
| Genetic information | ||
| wGRS | 1.371 (1.155 - 1.627) | <0.0001 |
MACE - Major adverse coronary events; HR - Hazard Ratio; CI - Confidence Interval; BMI - Body mass index; CAD - Coronary artery disease; SBP - Systolic blood pressure; DBP - Diastolic blood pressure; LDL - Low density lipoprotein; HDL - High density lipoprotein; CRP - C reactive protein; Cr Clearance - Creatinine Clearance; *Cockroft-Gault<60 ml/min; wGRS -Weighted genetic risk score; **Cox regression analysis entering each variable individually; Statistically significant for p<0.05.