Table 4 -. MACE discrimination using Harrel’s C-statistic, NRI and IDI methodology.

Models	C-index (95% CI)		P-value
TRFs	0.566 (0.539 - 0.593)
TRFs + wGRS	0.572 (0.545 - 0.599)		0.0003(a)
TRFs + clinical + wGRS	0.622 (0.595 - 0.649)		<0.0001(b)
TRFs + clinical	0.620 (0.593 - 0.647)
TRFs + clinical + wGRS	0.622 (0.595 - 0.649)		0.004(c)
		NRI
	Total	MACE	Non-MACE
TRFs + clinical + wGRS	17.9% (7.9% - 27.9%)	25.9% (18.0% - 33.9%)	-8.0% (-14.2% - (-1.9%))
	p=0.0005	p<0.0001	p=0.010
		IDI
	0.7% (0.2% - 1.0%)	-	-
	p=0.002	-	-

MACE - Major adverse coronary event; NRI - Net reclassification index; IDI - Integrated discrimination index; TRFs - Traditional Risk Factors; wGRS - Weighted genetic risk score; Clinical - Clinical risk factors; CI - Confidence interval. (a) Comparison among TRFs+wGRS vs TRFs models; (b) Comparison between TRFs+clinical+wGRS vs TRFs models; (c) Comparison between TRFs+clinical+wGRS vs TRFs+clinical models. Statistically significant for p<0.05.