Table 1.
Patient and treatment characteristics by HPV Status.
| Variables | n | HPV-negative (%) | HPV-positive (%) | P-value |
|---|---|---|---|---|
| Age | ||||
| <65 years | 182 (60.1) | 89 (61.8) | 93 (58.5) | 0.556 |
| ≥65 years | 121 (39.9) | 55 (38.2) | 66 (41.5) | |
| Race/ethnicity | ||||
| White | 250 (82.5) | 111 (77.1) | 139 (87.4) | 0.052 |
| Black | 40 (13.2) | 24 (16.7) | 16 (10.1) | |
| Other | 13 (4.3) | 9 (6.3) | 4 (2.5) | |
| Gender | ||||
| Male | 253 (83.5) | 118 (81.9) | 135 (84.9) | 0.488 |
| Female | 50 (16.5) | 26 (18.1) | 24 (15.1) | |
| Primary Site | ||||
| Oropharynx | 270 (89.1) | 118 (81.9) | 152 (95.6) | 0.000 |
| Hypopharynx | 33 (10.9) | 26 (18.1) | 7 (4.4) | |
| Grade | ||||
| Well differentiated | 6 (2.7) | 4 (3.5) | 2 (1.8) | 0.046 |
| Moderately differentiated | 89 (39.4) | 53 (46.5) | 36 (32.1) | |
| Poorly/undifferentiated | 131(58.0) | 57 (50.0) | 74 (66.1) | |
| Unknown | 77 | 30 | 47 | |
| Tumor stage | ||||
| T1 | 32 (12.6) | 16 (13.9) | 16 (11.6) | 0.082 |
| T2 | 78 (30.8) | 26 (22.6) | 52 (37.7) | |
| T3 | 58 (22.9) | 30 (26.1) | 28 (20.3) | |
| T4 | 85 (33.6) | 43 (37.4) | 42 (30.4) | |
| TX | 50 | 29 | 21 | |
| Nodal stage | ||||
| N0 | 19 (6.4) | 11 (7.9) | 8 (5.1) | 0.001 |
| N1 | 47 (15.8) | 33 (23.7) | 14 (8.9) | |
| N2 | 193 (65.0) | 75 (54.0) | 118 (74.7) | |
| N3 | 38 (12.8) | 20 (14.4) | 18 (11.4) | |
| NX | 6 | 5 | 1 | |
| Treatment paradigm | ||||
| C | 82 (27.1) | 44 (30.6) | 38 (23.9) | 0.033 |
| C+R | 181 (59.7) | 86 (59.6) | 95 (59.7) | |
| C+S | 11 (3.6) | 7 (4.9) | 4 (2.5) | |
| C+R+S | 29 (9.6) | 7 (4.9) | 22 (13.8) | |
| Bone metastases | ||||
| No | 220 (74.3) | 103 (73.0) | 117 (75.5) | 0.632 |
| Yes | 76 (25.7) | 38 (27.0) | 38 (24.5) | |
| Unknown | 7 | 3 | 4 | |
| Brain metastases | ||||
| No | 289 (98.0) | 135 (96.4) | 154 (99.4) | 0.172 |
| Yes | 6 (2.0) | 5 (3.6) | 1 (0.6) | |
| Unknown | 8 | 4 | 4 | |
| Liver metastases | ||||
| No | 254 (86.1) | 119 (85.0) | 135 (87.1) | 0.603 |
| Yes | 41 (13.9) | 21 (15.0) | 20 (12.9) | |
| Unknown | 8 | 4 | 4 | |
| Lung metastases | ||||
| No | 151 (51.0) | 68 (47.9) | 83 (53.9) | 0.302 |
| Yes | 145 (49.0) | 74 (52.1) | 71 (46.1) | |
| Unknown | 7 | 2 | 5 |
C, Chemotherapy; N, nodal; R, Radiotherapy; S, Surgery; T, tumor; X, unknown.