Table 1.
mRNA expression levels of genes after MEHP exposure at the end of 24 h
| Control | DMSO | 0.001 μM | 0.01 μM | 0.1 μM | 1 μM | 10 μM | |
|---|---|---|---|---|---|---|---|
| FOXO-1 | +0.10 | +0.01 | –0.16 | –0.29 | −0.43 | –1.21 | –1.25a,b,c,d |
| PDX-1 | +0.21 | +0.19 | –0.17 | –0.32 | −0.98 | –1.19 | –1.52a,b,c,d,e |
| SIRT-1 | +0.11 | +0.12 | –0.54 | –0.77 | −1.14a,b,c,f,g | –1.65a,b,c,g | –1.90a,b,c,d,e |
| INS-1 | +0.50 | +0.48 | –0.20a,b | –0.70 | −1.10 | –1.50 | –2.10a,b,c,d,e |
| INS-2 | +0.49 | +0.47 | –0.10 | –0.48 | −1.52 | –1.73a,b,c | –2.01 |
| P53 | +0.10 | +0.18 | +0.56 | +0.76 | +0.98 | +0.99 | +1.56a,b,c |
| BCL-2 | +0.43 | +0.39 | –0.16 | –0.17 | −0.32 | –1.32 | –1.33a,b,c,d,e |
| BCL-XL | +0.21 | +0.24 | –0.26 | –0.38 | −0.59 | –0.94a,b,c,d,g | –1.55 |
aDifferent from control group (P < 0.05).
bDifferent from DMSO group (P < 0.05).
cDifferent from 0.001 μM of MEHP dose group (P < 0.05).
dDifferent from 0.01 μM of MEHP dose group (P < 0.05).
eDifferent from 0.1 μM of MEHP dose group (P < 0.05).
fDifferent from 1 μM of MEHP dose group (P < 0.05).
gDifferent from 1 μM of MEHP dose group (P < 0.05). [(+) increase of mRNA levels, (−) decrease of mRNA levels].