Table 3.
mRNA expression levels of genes after MEHP exposure at the end of 48 h
| Control | DMSO | 0.001 μM | 0.01 μM | 0.1 μM | 1 μM | 10 μM | |
|---|---|---|---|---|---|---|---|
| FOXO-1 | +0.10 | +0.01 | –0.11 | –0.21 | −0.63 | –1.03 | −1.25a,b.c.d |
| PDX-1 | +0.21 | +0.22 | –0.17 | –0.22 | −0.58 | –0.79 | −1.62a,b,c,d,e |
| SIRT-1 | +0.12 | +0.14 | –0.43 | –0.67 | −1.10a,b,c,f,g | –1.21a,b,c,g | −1.80a,b,c,d,e |
| INS-1 | +0.50 | +0.51 | –0.20a,b | –0.87 | −1.15 | –1.40 | −1.10a,b,c,d,e |
| INS-2 | +0.39 | +0.45 | –0.15 | –0.42 | −1.13 | –1.33a,b,c | −1,55 |
| P53 | +0.10 | +0.17 | +0.66 | +0.65 | +0.70 | +1.33 | +2.56a,b,c |
| BCL-2 | +0.53 | +0.59 | –0.36 | –0.44 | −0.78 | –1.36 | −1.89a,b,c,d,e |
| BCL-XL | +0.31 | +0.34 | –0.21 | –0.55 | −0.57 | –0.84a,b,c,d,g | −1.87 |
aDifferent from control group (P < 0.05).
bDifferent from DMSO group (P < 0.05).
cDifferent from 0.001 μM of MEHP dose group (P < 0.05).
dDifferent from 0.01 μM of MEHP dose group (P < 0.05).
eDifferent from 0.1 μM of MEHP dose group (P < 0.05).
fDifferent from 1 μM of MEHP dose group (P < 0.05).
gDifferent from 10 μM of MEHP dose group (P < 0.05). [(+) increase of mRNA levels, (−) decrease of mRNA levels].