Table 4.
mRNA expression levels of genes after MBP exposure at the end of 48 h
| Control | DMSO | 0.001 μM | 0.01 μM | 0.1 μM | 1 μM | 10 μM | |
|---|---|---|---|---|---|---|---|
| FOXO-1 | +0.10 | +0.01 | –0.26 | –0.29 | −0.55 | –1.11 | −1.25a,b,c,d |
| PDX-1 | +0.11 | +0.10 | –0.20 | –0.31 | −0.39 | –0.67 | −0.52.a,b,c,d,e |
| SIRT-1 | +0.11 | +0.11 | –0.68 | –0.55 | −1.04a,b,c,f,g | –1.88a,b,c,g | −2.01a,b,c,d,e |
| INS-1 | +0.42 | +0.24 | –0.24a,b | –0.52 | −1.22 | –1.18 | −1.10a,b,c.d,e |
| INS-2 | +0.22 | +0.27 | –0.43 | –0.44 | −1.34 | –1.31a,b,c | −1.89 |
| P53 | +0.09 | +0.11 | +0.16 | +0.27 | +0.65 | +0.76 | +1.44a,b,c |
| BCL-2 | +0.43 | +0.39 | –0.16 | –0.17 | −0.32 | –1.32 | −1.33a,b,c,d,e |
| BCL-XL | +0.21 | +0.24 | –0.26 | –0.38 | −0.59 | –0.94a,b,c,d,g | −1.55 |
aDifferent from control group (P < 0.05).
bDifferent from DMSO group (P < 0.05).
cDifferent from 0.001 μM of MBP dose group (P < 0.05).
dDifferent from 0.01 μM of MBP dose group (P < 0.05).
eDifferent from 0.1 μM of MBP dose group (P < 0.05).
fDifferent from 1 μM of MBP dose group (P < 0.05).
gDifferent from 10 μM of MBP dose group (P < 0.05). [(+) increase of mRNA levels (−) decrease of mRNA levels].