Table 6.
mRNA expression levels of genes after MBP exposure at the end of 72 h
| Control | DMSO | 0.001 μM | 0.01 μM | 0.1 μM | 1 μM | 10 μM | |
|---|---|---|---|---|---|---|---|
| FOXO-1 | +0.15 | +0.11 | –0.24 | –0.51 | –0.89 | –1.56 | –1.99a,b,c,d |
| PDX-1 | +0.20 | +0.18 | –0.25 | –0.46 | –0.56 | –0.89 | –1.45a,b,c,d,e |
| SIRT-1 | +0.11 | +0.13 | –0.66 | –0.78 | –1.08a,b,c,f,g | –1.45a,b,c,g | –2.10a,b,c,d,e |
| INS-1 | +0.49 | +0.47 | –0.19a,b | –0.45 | –0.98 | –1.12 | –2.56a,b,c,d,e |
| INS-2 | +0.47 | +0.45 | –0.21 | –0.76 | –1.67 | –2.23a,b,c | –2.98 |
| P53 | +0.14 | +0.17 | +0.87 | +0.99 | +1.98 | +2.46 | +3.56a,b,c |
| BCL-2 | +0.33 | +0.35 | –0.46 | –0.67 | –1.232 | –1.87 | –2.45a,c,d,e |
| BCL-XL | +0.20 | +0.26 | –0.34 | –0.42 | –1.33 | –1.94a,b,c,d,g | –2.61 |
aDifferent from control group (P < 0.05).
bDifferent from DMSO group (P < 0.05).
cDifferent from 0.001 μM of MBP dose group (P < 0.05).
dDifferent from 0.01 μM of MBP dose group (P < 0.05).
eDifferent from 0.1 μM of MBP dose group (P < 0.05).
fDifferent from 1 μM of MBP dose group (P < 0.05).
gDifferent from 10 μM of MBP dose group (P < 0.05). [(+) increase of mRNA levels. (−) decrease of mRNA levels].