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. 2021 Apr 26;10(3):409–417. doi: 10.1093/toxres/tfaa107

Figure 2 .

Figure 2

Baicalin ameliorates apoptosis in 6-OHDA-treated C. elegans. The levels of (a) c-caspase-3 and (b) Bcl-2 proteins in C. elegans were evaluated by western blotting after treating the worms with 6-OHDA. Baicalin significantly reversed 6-OHDA-induced increase in c-caspase-3 and decrease in Bcl-2 levels. Results of the RT-PCR analysis of (c) ced-3 and (d) ced-9 gene expression in C. elegans after treatment with 6-OHDA. Baicalin effectively reversed 6-OHDA-induced changes in the gene expression of ced-3 and ced-9. Data are presented as mean ± SEM. ###, ##, and # indicate P < 0.001, 0.01, and 0.05, respectively, when data are compared to those for the vehicle-treated group. ***, **, and * indicate P < 0.001, 0.01, and 0.05, respectively, when data are compared to those for the worms treated with both 6-OHDA and the vehicle.