TABLE 1.

Summary of SNS-intestinal immunity manifestations in different diseases.

Disorder	Alterations of intestinal mucosal barrier	Intestinal immune/inflammatory responses	References
IBD	Depletion rate of goblet cells ↑	Inflammation grade of the colon↑; Inflammatory cytokines ↑	Willemze et al. (2018), Willemze et al. (2019a), Willemze et al. (2019b), Agac et al. (2018)
	AMP Reg3 γ expression↓
Melanin precipitation	Intestinal mucosal immune activation	Intestinal mucosa HDC+ MC ↑	Yamate et al. (2011)
Stroke	Intestinal mucosal barrier permeability ↑	Inducing MMΦ to differentiate into inflammatory phenotypes	Liu et al. (2019)
	Intestinal bacteria translocation ↑	Activate CHAT+ T cell
	TREM1 receptor ↑	Inducing CAIP pathway