TABLE 1.
Genetic changes of variants P.1 and P.2 from Uruguay compared to the Wuhan-Hu-1 SARS-CoV-2 reference sequence (GenBank accession number NC_045512)
| Variant name | Genome region (position) | Codon change | Amino acid change (position) |
|---|---|---|---|
| P.1 | ORF1ab-nsp3 (3827–3829) | TCA→TTA | S→L (370) |
| P.1 | ORF1ab-nsp3 5648–5650 | AAA→CAA | K→Q (977) |
| P.2 | ORF1ab-nsp5 (10667–10669) | TTA→GTA | L→V (205) |
| P.1 | ORF1ab-nsp6 (11288–11296) | Del (TCTGGTTTT) | SGF (106–108) |
| P.2 | ORF1ab-nsp7 (12053–12055) | CTT→TTT | L→F (71) |
| P.1/P.2 | ORF1ab-nsp-12 (14407–14409) | CCT→CTT | P→L (323) |
| P.1 | ORF1ab-nsp-13 (17257–17259) | GAG→GAT | E→D (341) |
| P.1 | S (21614–21617) | CTT→TTT | L→F (18)a |
| P.1 | S (21620–21622) | ACC→AAC | T→N (20)a |
| P.1 | S (21638–21640) | CCT→TCT | P→S (26)a |
| P.1 | S (21974–21976) | GAT→TAT | D→Y (138)a |
| P.1 | S (22130–22132) | AGG→AGT | R→S (190)a |
| P.1 | S (22811–22813) | AAG→ACG | K→T (417)a |
| P.1/P.2 | S (23012–23014) | GAA→AAA | E→K (484)a |
| P.1 | S (23063–23065) | AAT→TAT | N→Y (501)a |
| P.1/P.2 | S (23402–23404) | GAT→GGT | D→G (614) |
| P.1 | S (23525–23527) | CAT→TAT | H→Y (655)a |
| P.1 | S (24641–24643) | ACT→ATT | T→I (1027)a |
| P.1/P.2 | S (25088–25090) | GTT→TTT | V→F (1176) |
| P.2 | S (25247–25249) | ATG→ATT | M→I (1229) |
| P.1 | ORF3a (26149–26151) | TCC→CCC | S→P (253) |
| P.2 | M (26589–26561) | GTA→TTA | V→L (23) |
| P.1 | ORF8 (28167–28169) | GAA→AAA | E→K (92) |
| P.1 | Intergenic region (28263–28266) | Ins (AACA) | |
| P.1 | N (28515–28517) | CCA→CGA | P→R (80) |
| P.2 | N (28632–28634) | GCT→TCT | A→S (119) |
| P.1/P.2 | N (28844–28846) | AGG→AAA | R→K (203) |
| P.1/P.2 | N (28887–28889) | GGA→CGA | G→R (204) |
| P.2 | N (28997–28999) | ATG→ATT | M→I (234) |
a
P.1-specific substitutions on the spike (S) protein.