Skip to main content
. Author manuscript; available in PMC: 2021 Dec 24.
Published in final edited form as: J Med Chem. 2020 Dec 16;63(24):16012–16027. doi: 10.1021/acs.jmedchem.0c01874

Scheme 3. Synthesis of 6-Chloro-2-iodopurine 17a.

Scheme 3.

aReagents and conditions: (a) 2,3-dihydropyran, PTSA, THF, 80 °C; (b) n-Bu3SnCl, LiTMP, THF/n-hexane (2:1), −78 °C; (c) I2, THF, rt; and (d) 10 mol % CuCl2, EtOH/H2O (19:1), rt.