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. Author manuscript; available in PMC: 2021 Dec 24.
Published in final edited form as: J Med Chem. 2020 Dec 16;63(24):16012–16027. doi: 10.1021/acs.jmedchem.0c01874

Scheme 2. Synthesis of Truncated 1′-Homologated 4′-Thioadenosine Derivatives, 4a–4ha.

Scheme 2.

aReagents and conditions: (a) NaH, 2,6-dichloropurine or 6-chloropurine, DMF, rt; (b) 2 N HCl, THF, rt; and (c) 3-halobenzylamines, Et3N, EtOH, rt.