Figure 1.

(A) Phase diagram of the symmetric ternary protein–RNA–nucleoplasm mixture and the bulk free energy governing the solution thermodynamics f_bulk(φ₁, φ₂, φ₃) for χ = 3. The solid-line and dash-line correspond to the spinodal and binodal curves, respectively. (B) The schematic of the minimal reactive nucleoplasm model. Shown are the main reactive components (protein, RNA, DNA-seed, nucleoplasm reservoir), the corresponding reactive processes involving each components as well as their spatial generation profiles.