Figure 2.

Distinct role of endothelial cell- and macrophage-secreted Wnts in regulating proliferation and compensation of hepatic functions during liver regeneration. Following PH, hepatocytes bifurcate into two populations: one (left), under the control of Wnt2 and Wnt9b from sinusoidal endothelial cells, expresses cyclin D1 and enters cell cycle, contributing to the regain of hepatic mass through proliferation; second (right), under the control of Wnts from macrophages, expresses GS, cyp2e1, and other metabolic, biosynthetic, and detoxification-related genes, thus ensuring continual hepatic function.