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Shikonin inhibits the Warburg effect and regulates the glycometabolism of A549 and H446 cells in a dose-dependent manner. A549 and H446 cells were treated with 0, 10, 20 or 50 µM shikonin for 24 h. Shikonin inhibited (A) glucose uptake, (B) lactate levels and (C) ATP levels in A549 cells. Shikonin inhibited (D) glucose uptake, (E) lactate levels and (F) ATP levels in H446 cells. *P<0.05.
