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. 2021 Jun 4;24(2):560. doi: 10.3892/mmr.2021.12199

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Copyright: © Sha et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 5. — Overexpression of PFKFB2 accelerates the Warburg effect in lung cancer cells. (A) Overexpression of PFKFB2 in A549 cells increased (A) glucose uptake, (B) lactate levels and (C) ATP levels. Overexpression of PFKFB2 in H446 cells increased (D) glucose uptake, (E) lactate levels and (F) ATP levels. *P<0.05. PFKFB2, 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2; NC, negative control.