Figure 1.

Nano-immune-engineering approaches to augment the cancer-immunity cycle. Ultra-pH-sensitive nanoparticles are loaded with distinct payloads depending on specific applications: tumor antigen (yellow), innate immune activator (green), or agent that reprograms tumor microenvironment (red). These molecules are targeted to the tumor microenvironment or the draining lymph nodes with precise spatiotemporal control, tilting the cancer-immunity balance toward antitumor immunity.