Table 1.
Clinical and biological findings of patients with KIN in families A and Z
Patient No | Sexe | AN | AERSD | Smoking | Personal history | Cause of renal examination | HMG | TR | Death | Initial creatinine (µmol/l) | eGFR ml/min/1.73m2 | Cytolisis | Cholestasis | VST | KB | Liver Biopsy | |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Family A | IV-2 | M | 36 | 36 | No | 0 | Convulsion | 0 | Yes | No | 900 | 9.9 | Yes | Yes | – | No | No |
IV-7 | M | 39 | 43 | Yes | Appendectomy | Donor check up | 0 | Yes | Yes | 161 | 69.4 | No | Yes | – |
Yes K + |
Yes K- |
|
IV-11 | M | 26 | 29 | No | 0 | Donor Check up | 0 | No | Yes | 197 | 53.38 | Yes | Yes | – | No | No | |
IV-12 | M | 32 | 38 | No | Urethritis | Donor Check up | 0 | No | No | 141 | 65.9 | Yes | Yes | – |
Yes K + |
No | |
Family Z | II-2 | M | 31 | 36 | No | 0 | Fortuitously | 0 | Yes | Yes | 1000 | ND | No | No | – | No | No |
II-3 | M | 25 | 33 | No | Epilepsy and visceral leishmaniasis | Donor check up | 0 | No | No | 200 | ND | No | No | – |
Yes K + |
Yes K- |
AN, age at the time of the discovery of nephropathy; AERSD, Age at the time of the end of renal stage disease; HMG, hepatomegaly; TR, transplantation; eGFR, estimated glomerular filtration rate; VST, viral serology test; KB, Kidney biopsy; K, Karyomegaly; + , present; -, absent; ND, no data