Table 3.
Analysis of 7 selected genes by GO and KEGG pathway enrichment. FDR, false discovery rate. GO, gene ontology; BP, biological process, CC, cellular component; MF, molecular function; KEGG, Kyoto Encyclopedia of Genes and Genomes; DEMs, differentially expressed miRNAs
| Category | Term | Count | % | PValue | Genes | FDR |
|---|---|---|---|---|---|---|
| GOTERM_BP_DIRECT | GO:0048146 ~ positive regulation of fibroblast proliferation | 3 | 0.263 | 1.51E-04 | CCNB1, CCNA2, FN1 | 0.174735 |
| GOTERM_BP_DIRECT | GO:0051301 ~ cell division | 3 | 0.263 | 0.006147477 | CCNB1, MAD2L1, CCNA2 | 6.892135 |
| GOTERM_BP_DIRECT | GO:0051436 ~ negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle | 2 | 0.175 | 0.025106263 | CCNB1, MAD2L1 | 25.50655 |
| GOTERM_BP_DIRECT | GO:0051437 ~ positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition | 2 | 0.175 | 0.026854324 | CCNB1, MAD2L1 | 27.03882 |
| GOTERM_BP_DIRECT | GO:0022617 ~ extracellular matrix disassembly | 2 | 0.175 | 0.026854324 | SPP1, FN1 | 27.03882 |
| GOTERM_BP_DIRECT | GO:0031145 ~ anaphase-promoting complex-dependent catabolic process | 2 | 0.175 | 0.027901906 | CCNB1, MAD2L1 | 27.94322 |
| GOTERM_BP_DIRECT | GO:0071456 ~ cellular response to hypoxia | 2 | 0.175 | 0.033820471 | CCNB1, CCNA2 | 32.86331 |
| GOTERM_BP_DIRECT | GO:0000086 ~ G2/M transition of mitotic cell cycle | 2 | 0.175 | 0.047971221 | CCNB1, HMMR | 43.40814 |
| GOTERM_BP_DIRECT | GO:0042787 ~ protein ubiquitination involved in ubiquitin-dependent protein catabolic process | 2 | 0.175 | 0.053446406 | CCNB1, MAD2L1 | 47.06463 |
| GOTERM_BP_DIRECT | GO:0030198 ~ extracellular matrix organization | 2 | 0.175 | 0.068031098 | SPP1, FN1 | 55.77698 |
| GOTERM_BP_DIRECT | GO:0001525 ~ angiogenesis | 2 | 0.175 | 0.077092848 | CXCL8, FN1 | 60.50819 |
| GOTERM_CC_DIRECT | GO:0000922 ~ spindle pole | 2 | 0.175 | 0.035359174 | CCNB1, MAD2L1 | 26.96429 |
| GOTERM_CC_DIRECT | GO:0005615 ~ extracellular space | 3 | 0.263 | 0.067058677 | CXCL8, SPP1, FN1 | 45.44016 |
| GOTERM_CC_DIRECT | GO:0005576 ~ extracellular region | 3 | 0.263 | 0.092078284 | CXCL8, SPP1, FN1 | 56.9647 |
| GOTERM_MF_DIRECT | GO:0005515 ~ protein binding | 7 | 0.613 | 0.019847501 | CCNB1, MAD2L1, CXCL8, CCNA2, SPP1, FN1, HMMR | 13.51086 |
| KEGG_PATHWAY | hsa04512:ECM-receptor interaction | 3 | 0.263 | 0.002294922 | SPP1, FN1, HMMR | 2.054976 |
| KEGG_PATHWAY | hsa04914:Progesterone-mediated oocyte maturation | 3 | 0.263 | 0.002294922 | CCNB1, MAD2L1, CCNA2 | 2.054976 |
| KEGG_PATHWAY | hsa04110:Cell cycle | 3 | 0.263 | 0.004611117 | CCNB1, MAD2L1, CCNA2 | 4.090835 |
| KEGG_PATHWAY | hsa05146:Amoebiasis | 2 | 0.175 | 0.088997082 | CXCL8, FN1 | 56.93087 |
| KEGG_PATHWAY | hsa04620:Toll-like receptor signaling pathway | 2 | 0.175 | 0.088997082 | CXCL8, SPP1 | 56.93087 |
| KEGG_PATHWAY | hsa04114:Oocyte meiosis | 2 | 0.175 | 0.093026279 | CCNB1, MAD2L1 | 58.62208 |