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. 2021 May 12;12(6):1011–1016. doi: 10.1021/acsmedchemlett.1c00162

Table 2. Biological Activity of A-1293102 and Compound 5a.

  Ki (nM)
 10% HS EC50 (μM)
compound BCL-XL BCL-2 MCL-1 MOLT-4 RS4;11
4 (A-1293102) 0.43 193 >3900 0.08 >5
5 0.14 31 >1560 >5 >5
A-11554637,25 <0.1 80 >444 0.07 >5
A-13318527,26 <0.1 6.1 142 0.006 >5
navitoclax7 <0.1 <0.1 >224 0.30 0.11
a

All assays were run at least in quadruplicate.