Table 3. SPR Binding Kinetics of A-1293102 and Compound 5 to BCL-XL.
| compound | kon (M–1 s–1) | koff (s–1) | KD (nM) | t1/2 (min) |
|---|---|---|---|---|
| A-1293102 | 5.88 × 105 | 0.000234 | 0.4 | 49 |
| 5 | 2.18 × 107 | 0.0109 | 0.5 | 1 |
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