Table 5. Multiple-Species PK Data for Compound 23.

	ratc	moused	doge	monkeyf
Cl (mL/min/kg)a	25	21	14	23
Vss (L/g)a	0.70	1.0	1.6	1.2
T1/2 (h)a	1.4	1.8	3.6	2.0
Cmax (μg/mL)b	0.15	4.8	1.3
AUC (μg/h/mL)b	0.60	16	9.9
%Fb	29	100	66

^aParameters obtained after IV dosing.

^bParameters obtained after PO dosing.

^cIV dosing: 0.9 mpk; PO dosing: 2.6 mpk with 0.5% MC/0.1% Tween 80 formulation.

^dIV dosing: 0.8 mpk; PO dosing: 13 mpk with 0.5% MC/0.1% Tween 80 formulation.

^eIV dosing: 0.8 mpk; PO dosing: 12 mpk with 30% PG/10%Solutol/1% HPMC-AS formulation,

^fIV dosing: 0.9 mpk.