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. 2021 Jun 1;12(6):1038–1049. doi: 10.1021/acsmedchemlett.1c00218

Figure 5.

Figure 5

Oral efficacy of compound 19 in mouse formalin paw test. Measurement of formalin-induced nociceptive behaviors in mice (C57BL/6 mice) following administration of vehicle (10% Tween 80; dose volume = 5 mL/kg) or rising oral doses of compound 19. Compound 19 was administered 15 min prior to formalin injection and plasma concentrations were evaluated 1.5 h postadministration. Data were analyzed using within-subject ANOVA to determine main effects and 1 sample t test to compare to vehicle (N = 8/group); **P > 0.001.