Table 1. Mouse Formalin Paw Efficacy and Mouse Na_v1.7 Inhibition Relationships under Depolarized and Hyperpolarized Assay Protocols.

^aEstimated depolarized or hyperpolarized state potency as measured by PatchXpress in HEK293 cells stably expressing mouse Na_v1.7, IC₅₀ values are estimated from ≥3 cellular measurements at varying compound concentrations and standard deviation <50% of average value shown.

^bMouse formalin paw test performed as described in ref (22).

^cEstimated hyperpolarized state potency as measured by Qube in HEK293 cells stably expressing human Na_v1.7 or Na_v1.6; IC₅₀ values are estimated from ≥3 cellular measurements at varying compound concentrations; * = estimated value.