Table 5. Estimated Human Dose Projections Based on Changing Ctrough Targets of Compound 19.
| Ctrough target | regimen | dose (mg) |
|---|---|---|
| 0.04× Nav1.7 IC50 | BID | 40 |
| 1× Nav1.7 IC50 | BID | 960 |
| 4.8× Nav1.7 IC50 | BID | 4600 |
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