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. 2021 May 10;12(6):996–1004. doi: 10.1021/acsmedchemlett.1c00155

Figure 4.

Figure 4

SD-91 selectively degrades STAT3 protein in cells. (A) Chemical structures of two control STAT3 inhibitors SI-191 and SI-109. (B) Western blotting of STAT proteins in MOLM-16 cells treated with different compounds at indicated concentrations for 4 h. GAPDH was used as the loading control. (C) Densitometry of STAT3 and GAPDH proteins in the MOLM-16 cell line treated with SD-91 or SD-36 for 4 h. (D) Western blotting of STAT proteins in the SU-DHL-1 cells. (E) Western blotting of STAT proteins in the SUP-M2 cells. (F) Quantitative proteomics analysis of MOLM-16 cells treated with 1 or 10 μM of SD-91 for 4 h.