Table 2. SAR (Continued)^a.

					IC50 (nM)
compd	R1	R2	MW	LE	TNKS1 FP	TNKS2 FP	β-cat luc
20	H	H	485.5	0.32	7.9	79.4	63.1
21	CH3	H	499.5	0.32	4.0	63.1	20.0
22	OCH3	H	515.5	0.30	8.1	125.9	20.0
23	F	H	503.5	0.28	39.8	316.2	63.1
24	Cl	H	519.9	0.30	15.8	125.9	63.1
25	CH3	F	517.4	0.30	6.3	79.4	20.0
26	CH3	CH3	513.5	0.29	15.8	79.4	251.2

^aThe values are the geometric mean of at least two determinations. All individual values are within 25% of the mean.