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Rhox10 drives LINE1 promoter methylation. (A, Top) The degree of methylation at each CpG site in the SN1 transgene promoter in testes from E16.5 Rhox10-null; SN1+/− (KO) and SN1+/− (WT) mice. (Bottom) Bisulfite analysis data of individual samples. *P < 0.05. (B) Bisulfite analysis, performed as in A, of purified germ cells from E16.5 Rhox10-null; SN1+/− (KO) and SN1+/− (WT) mice testes. *P < 0.05.
