FIGURE 6.

Inhibition and activation of the P38MAPK pathway regulates endoplasmic reticulum stress and copper transport (A) Western Blot detects the protein expression of GRP78, XBP1, copper transporter ATP7B, CCS after treatment with the P38MAPK pathway inhibitor SB203580; (B) The mRNA levels of GRP78, XBP1, ATP7B, CCS in cells treated with the SB203580 (C) Western blotting analysis and densitometric quantification of GRP78, XBP1, ATP7B, and CCS protein levels in HSCs treated with the P38MAPK pathway agonists dehydrocorydaline; (D) mRNA levels of GRP78, XBP1, ATP7B, and CCS in HSCs treated with dehydrocorydaline. The data are expressed as the mean ± SEM (n = 4). ^* p < 0.05, **p < 0.01 vs. Control group; ^# p < 0.05, ^## p < 0.01 vs. CuSO₄ group.