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. 2021 May 31;12:653272. doi: 10.3389/fphar.2021.653272

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Copyright © 2021 Kong, Huang, Luan, Liu, Ye and Wu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Protein and mRNA expression in liver tissues of Wistar rats treated with copper. Western blotting analysis and densitometric quantification of ASIC1a, α-SMA, and Collagen-I (A), ERS marker protein GRP78, XBP1 (C), ATP7B, and CCS (E) in the Wistar rats in each group. Changes in the gene expression of ASIC1a, α-SMA, and Collagen-I (B), the ERS marker protein GRP78, XBP1 (D), ATP7B, and CCS (F) in the liver tissues of copper-treated rats after amiloride and penicillamine treatment (G) Serum levels of IL-6 and TNF-a in Wistar rats. Statistical analyses were performed using a t-test. The data are expressed as the mean ± SEM (n = 4). ^* p < 0.05, **p < 0.01 vs. Normal group; ^# p < 0.05, ^## p < 0.01 vs. HLD group.