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. 2021 May 31;12:653272. doi: 10.3389/fphar.2021.653272

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Copyright © 2021 Kong, Huang, Luan, Liu, Ye and Wu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Endoplasmic reticulum stress mediated by ASIC1a through the P38 MAPK signalling pathway contributes to the activation of HSCs and the degradation of ATP7B induced by copper.