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. 2021 May 31;9:657166. doi: 10.3389/fcell.2021.657166

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Copyright © 2021 Klatte-Schulz, Bormann, Voss, Melzer, Schmock, Bucher, Thiele, Moroder, Haffner-Luntzer, Ignatius, Duda and Wildemann.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Gene expression of ECM markers (A–D), integrins (E,F), MMPs (G–I), and TIMPs (J,K) in bursa-derived cells after 1 h and 4 h of mechanical loading per day for 3 days at 1 Hz. Values are given as normalized expression to the housekeeping gene HPRT and the unstimulated control (line at 1) using an efficiency corrected formula. Statistics: Dunn’s multiple comparison test for n = 5 individual donors. The # marks significant differences to the unstimulated control group with a p < 0.05. A dashed spanning line with gray asterix or a gray # marks differences with a p-value of < 0.1.