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. 2021 May 31;9:657166. doi: 10.3389/fcell.2021.657166

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Copyright © 2021 Klatte-Schulz, Bormann, Voss, Melzer, Schmock, Bucher, Thiele, Moroder, Haffner-Luntzer, Ignatius, Duda and Wildemann.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Protein secretion of Col I (A), MMP1 (B), MMP2 (C), and TIMP1 (D) from bursa-derived cells after 1 and 4 h of mechanical loading per day for 3 days at 1 Hz. The values are given as fold to the unstimulated control cells (line at 1). MMP1 secretion was below the detection limit in one or two of five donors for the 1 and 4 h stimulations, respectively. MMP3 secretion was below the detection limit in all samples. Statistics: Dunn’s multiple comparison test for n = 5 individual donors. A spanning line with asterisk or a # marks significant difference with a p-value of < 0.05. A dashed spanning line or a gray # marks differences with a p-value of < 0.1.