FIGURE 3.

(A) Representative images of vascularized hepatic lobule structure. (a) The schematic of the preset extrusion bioprinting describes the printing strategy for hepatic lobules. (b) Immunofluorescence images of hepatic lobule construct using preset bioprinting exhibit well-preserved structural integrity not seen in the Mix group. (B) Evaluation of hepatic functions. (a) Albumin secretion and urea production measured by ELISA are enhanced in the printed hepatic lobule. (b) CYP3A4 and CYP1A1 enzyme activities are upregulated in printed lobule construct (*p < 0.05). Reprinted with permission from Kang et al. (2020).