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. 2021 May 31;12:688259. doi: 10.3389/fphys.2021.688259

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Copyright © 2021 Li, Wang, Zhang and Su.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Cyp4a14 ablation enhanced α-smooth muscle actin (α-SMA), Col1a2, and smad3 expression in bile duct ligation (BDL) mice. (A) Cyp4a14 gene ablation markedly exacerbated BDL-induced α-SMA, Col1a2, and smad3 protein expression in the livers as assessed by an immunostaining analysis. (B) Western blot assay showing the protein levels of α-SMA, TGF-β1, and Col1a2. (C) Quantitative RT-PCR analysis showing the mRNA levels of Acta2, Tgfb1, Col1a1, Col1a2, Mmp2, Mmp9, Timp1, TgfbR1, Smad3, and Pparα. n = 6–7. *p < 0.05, WT + Sham and WT + BDL. ^#p < 0.05, WT + BDL and Cyp4a14^–/– + BDL. Scale bar = 100 μm.